Publications

 

2013

  • Rudenko, Andrii, Meelad Dawlaty, Jinsoo Seo, Albert Cheng, Jia Meng, Thuc Le, Kym Faull, Rudolf Jaenisch, and Li-Huei Tsai. “Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction.” Neuron 79.6 (2013): 1109-1122. ScienceDirect. Web. 18 Sept. 2013.
  • Wen-Yuan Wang, Ling Pan, Susan C Su, Emma J Quinn, Megumi Sasaki, Jessica C Jimenez, Ian R A Mackenzie, Eric J Huang, Tsai LH. Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. Nature 2013 September 15; doi:10.1038/nn.3514(Online).

 

2012

  • Gräff J, Rei D, Guan J, Wang W, Seo J, Henning K, Nieland T, Fass D, Kao P, Kahn M, Su S, Samiei A, Joseph N, Haggarty S, Delalle I, Tsai LH. An epigenetic blockade of cognitive functions in the neurodegeneration brain. Nature 2012 Feb 29;483(7388):222-6. doi: 10.1038/nature10849 (PMC Journal- In Process).
  • Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH. Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(7):741-6. (PMC Journal- In Process).
  • Calderon F, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabushi R, Ginty DD, Kolodkin AL, and Tsai LH. An Autism Spectrum Disorder Susceptibility Gene, TAO2, is Important for Basal Dendrite Formation in the Neocortex. Nat Neurosci 2012 Jun 10;15(7):1022-31. doi: 10.1038/nn.3141. (PMC Journal- In Process).
  • Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Groves Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Neuropharmacology. 2012 Jul 4. (In Press) (PMC Journal- In Process).
  • Su SC, Seo J, Pan JQ, Samuels BA, Rudenko A, Ericsson M, Neve RL, Yue DT, Tsai LH. Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron 2012 Aug 23;75(4):675-87. (PMC Journal- In Process).
  • Zhao WN, Cheng C, Theriault KM, Sheridan SD, Tsai LH, Haggarty SJ. A High-Throughput Screen for Wnt/β-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors. J Biomol Screen. 2012 Aug 24. (In Press) (PMC Journal- In Process).

 

2011

  • Siegle JH, Carlen M, Meletis K, Tsai LH, Moore CI, Ritt J. Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7529-32. PMCID: PMC 22256080.
  • Carlen M, Meletis K, Siegle JH, Cardin JA, Futai K, Vierling-Claassen D, Ruhlmann C, Jones SR, Deisseroth K, Sheng M, Moore CI, Tsai L-H. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior Mol Psychiatry. 2012 May;17(5):537-48. doi: 10.1038/mp.2011.31. PMCID: PMC3335079.
  • Pinheiro EM, Xie Z, Norovich AL, Vidaki M, Tsai LH, Gertler FB. Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. Nat Cell Biol. 2011 Jul 24;13(8):989-95. doi: 10.1038/ncb2292. PMCID: PMC3149714.
  • Buchman JJ, Durak O, Tsai L-H. ASPM regulates Wnt signaling pathway activity in the developing brain.Genes Dev. 2011 Sep 15;25(18):1909-14. doi: 10.1101/gad.16830211. PMCID: PMC3185963.
  • Guan JS, Su SC, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr S, Tsai L-H. Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLos One 6(9): e25735. doi:10.1371/journal.pone.0025735 PMCID: PMC3184170.
  • Giusti-Rodríguez P, Gao J, Gräff J, Rei D, Soda T, Tsai L-H. Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of beta-secretase (BACE1). J Neurosci. 2011 Nov 2;31(44):15751-6PMCID: PMC3248793.
  • Kim J, Su SC, Wang H, Cheng AW, Cassady JP, Lodato MA, Lengner CJ, Chung C-Y, Dawlaty MM, Tsai L-H, Jaenisch R. Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts. Cell Stem Cell. 2011 Nov 4;9(5):413-9. PMCID: PMC3210333.
  • Singh KK, DiRienzo G, Drane L, Mao Y, Flood Z, Madison J, Ferreira M, Bergen S, King C, Sklar P, Sive H, Tsai L-H. Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Neuron. 2011 Nov 17;72(4):545-58PMCID: PMC3387684.
  • Kwon E, Wang W, Tsai L-H. Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C, and TCF4 as miR-137 targets. Mol Psychiatry. 2011 Dec 20. doi: 10.1038/mp.2011.170 (PMC Journal- In Process).

 

2010

  • Ge X, Frank CL, Calderon F, Tsai L-H.  Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron, 2010.  Jan 28;65(2):191-203 PMCID: PMC2902371.
  • Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai L-H, Moore CI.  Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2.  Nat Protoc. 2010 Feb;5(2):247-54 (PMC Journal- In Process).
  • Buchman JJ, Tseng HC, Zhou Y, Frank CL, Xie Z, and Tsai L-H. Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron, 2010 May;66: 386-402 (PMC Journal- In Process).
  • Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai L-H, Yuan J.  Negative regulation of Vps34 by Cdk mediated phosphorylation.  Mol Cell.  2010.  May 28;38(4):500-511.  PMCID: PMC2888511.
  • Gao J, Wang WY, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai L-H.  A novel pathway regulates memory and plasticity via SIRT1 and miR-134.  Nature. 2010 Aug.  26;466(7310):1105-9. PMCID: PMC2928875.
  • Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai L-H.  Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.  Neuron. 2010 Jul 15;67(1):33-48.  PMCID: PMC2938013.
  • De Anda CF, Meletis K, Ge X, Rei D, Tsai L-H.  Centrosome motility is essential for initial axon formation in the neocortex.   J Neurosci 2010 Aug 4;30(31):10391-406. (PMC Journal- In Process).
  • Frank CL, Ge X, Xie Z, Zhou Y, Tsai L-H.  Control of ATF4 persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem. 2010 Oct 22;285(43):33324-37.  PMCID: PMC2963346.
  • Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai L-H, Deng CX, Alt FW.  Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.  Proc Natl Acad Sci USA. 2010 Dec 14;107(50):21790-4.PMCID: PMC3003110.

 

2009

  • Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai L-H.  Disrupted in Schizophrenia 1 regulates neural progenitor proliferation via modulation of GSK3/-catenin signaling. Cell, 2009, Mar 20; 136(6): 1017-31 PMCID: PMC2704382.
  • Guan J-S, Haggarty SJ, Giacometti E, Dannenberg J-H, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai, L-H. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature, 2009 May 7; 459(7243): 55-60 (PMC Journal- In Process).
  • Cardin JA, Carlen M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai L-H, Moore CI.  Driving fast-spiking cells induces gamma rhythm and controls sensory responses.  Nature, 2009 Jun 4; 459(7247): 663-7 (PMC Journal- In Process).
  • Orlando LR, Ayala R, Kett LR, Curley AA, Duffner J, Bragg DC, Tsai L-H, Dunah AW, Young AB. Phosphorylation of the homer-binding domain of group I metabotropic glutemate receptors by cyclin-dependent kinase 5.  J Neurochem. 2009 Jul;110(2):557-69. (PMC Journal- In Process).
  • Davis DA, Wilson MH, Giraud J, Xie Z, Tseng HC, England C, Herscovitz H, Tsai LH, Delalle I. Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol. 2009 Oct;7(10):e1000208. PMCID: PMC2748697.

 

2008

  • Calderon de Anda F, Gartner A, Tsai L-H, Dotti, C. Pyramidal neuron polarity axis is defined at the bipolar stage.  J Cell Sci, 2008 Jan 15;121(Pt 2):178-85.
  • Shim SY, Samuels BA, Wang J, Neumayer G, Belzil C, Ayala R, Shi Y, Shi Y, Tsai LH, Nguyen MD, Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth. J Biol Chem. 2008. May 2;283(18):12232-40 (PMC Journal- In Process).
  • Kim D, Frank C, Dobbin M, Tsunemoto R, Wu D, Peng P, Guan J, Lee B-H, Moy L, Gusti P, Broodie N, Mazitschek R, Delalle I, Haggarty S, Neve R, Lu Y, and Tsai L-H. Deregulation of HDAC1 by p25/Cdk5 in neurodegeneration. Neuron, 2008, 60: 803-817 PMCID: PMC2912147.
  • Meyer DA, Richer E, Benkovic SA, Hayashi K, Kansy JW, Hale CF, Moy LY, Kim Y, O’Callaghan JP, Tsai LH, Greengard P, Nairn AC, Cowan CW, Miller DB, Antich P, Bibb JA. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18561-6. PMCID: PMC2587606.

 

2007

  • Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai, L-H.  Recovery of learning and memory is associated with chromatin remodeling.  Nature 2007, 447: 178-182.
  • Yip YP, Capriotti C, Drill E, Tsai LH, Yip J. Cdk5 Selectively Affects the Migration of Different Populations of Neurons in the Developing Spinal Cord. J Comp Neurol. 2007;503(2):297-307.
  • Kim D, Nguyen MD, Fischer A, Sananbenesi F, Dobbin MM, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigsrver P, Sinclair DA, Tsai L-H.  SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis.  EMBO J 2007, 26: 3169-3179.
  • Sananbenesi F, Fischer A, Schrick C, Neve R, Radulovic J, Tsai L-H. A Hippocampal Cdk5 Pathway Regulates Extinction of Contextual Fear.  Nat Neurosci. 2007, 10(8): 1012-9.
  • Choe EA, Liao L, Zhou JY, Cheng D, Duong DM, Jin P, Tsai LH, Peng J. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. J Neurosci. 2007, 27(35): 9503-12.
  • Xie Z, Moy L, Sanada K, Zhou Y, Buchman J, Tsai L-H. Cep120 and TACCs Control Interkinetic Nuclear Migration and the Neural Progenitor Pool. Neuron 2007, 56: 79-93.
  • Samuels, BA, Hsueh Y-P, Shu T, Liang H, Tseng H-C, Hong C-J, Su SC, Neve R, Yue, DT, Tsai, L-H.  Cdk5 promotes synapse formation by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 2007, 56: 823-837.

 

2006

  • ShuT., TsengH.C., ZhouY., FischerA., SternP., CoquelleF., ReinerO., Tsai L-H. Doublecortin-like Kinase Controls Neurogenesis by Regulating the Mitotic Spindle. Neuron 200649:25-39.
  • Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai, L-H.  p25/Cdk5 induces production and intraneuronal accumulation of amyloid beta in vivo.  J Neurosci 2006, 26: 10536-41.

2005

  • Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A.  Mechanism of Cdk5/p25 binding by Cdk inhibitors.  J Med Chem 2005, 48(3): 671-9.
  • Sanada K, Tsai L-H.  G protein beta/gamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors.  Cell 2005, 122: 119-131.
  • Tseng H-C, Ovaa H, Wei N, Ploegh H, Tsai L-H.  Phosphoproteomic analysis with a solid-phase capture-release-tag approach.  Chemistry and Biology 2005, 12: 769-777.
  • Park, SK, Nguyen MD, Fischer A, Luke MP, Affar EB, Dieffenbach, PB, Tseng HC, Shi Y, Tsai L-H.  Par4 links dopamine signaling and depression.  Cell 2005, 122: 275-287.
  • Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai L-H.  Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.  Neuron, 2005, 48: 825-838.

 

2004

  • Kao SC, Krichevsky AM, Kosic K, Tsai, L-H. BACE1 suppression by RNA interference in primary cortical neurons.   J Biol Chem 2004, 279: 1942-1949.
  • Hammond V, Tsai L-H, Tan SS.  Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35.  J Neurosci 2004, 24: 576-87.
  • Tanaka T, Serneo FF, Tseng H-C, Kulkarni AB, Tsai L-H, Gleeson JG.  Cdk5 phosphorylation of doublecortin Ser297 regulates its effect on neuronal migration. Neuron 2004, 41:215-227.
  • Morabito MA, Sheng M, Tsai L-H.  The cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD95 in neurons.   J Neurosci 2004, 24: 865-876.
  • Beffert U, Weeber E, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J.  Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.  J Neurosci2004, 24: 1897-1906.
  • Sanada K, Gupta A, Tsai L-H.  Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis.  Neuron 2004, 22: 197-211.
  • Nguyen MD, Shu T, Sanada K, Lariviere RC, Tseng,HC, Park SK, Julien JP, Tsai L-H.  A NUDEL dependent mechanism of Neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol 2004, 6: 597-608.
  • Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai L-H.  Ndel1 operates in a common pathway with Lis1 and cytoplasmic dynein to regulate cortical neuronal positioning.  Neuron 2004, 44: 263-277.
  • Moy LY, Tsai L-H.  Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. J Biol Chem. 2004;279(52):54487-93.
  • Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A.  Coupling PAF signaling to dynein regulation; structure of Lis1 in complex with PAF-acetylhydrolase.  Neuron  2004, 809-821.

 

2003

  • Patzke, H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai L-H.  Partial rescue of the p35-/- brain phenotype by low expression of a NSE p25-transgene.  J Neurosci 2003; 23(7):2769.
  • Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai L-H, Dobyns W, Ledbetter D, Hirotsune, S, Wynshaw-Boris A. 14-3-3 epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet. 2003; 34: 274-85.
  • Xie Z, Sanada K, Samuels B, Shih H, Tsai L-H. Serine 732 Phosphorylation of FAK by Cdk5 is Important for Microtubule Organization, Nuclear Movement and Neuronal Migration. Cell 2003;114: 469-482.
  • Lee M-S, Kao S-c, Lemere CA, Xia W, Tseng H-C, Zhou Y, Neve R, Ahlijanian MK, Tsai L-H. APP Processing is Regulated by Cytoplasmic Phosphorylation.  J Cell Biol 2003, 163:83-95.
  • Cruz JC, Tseng H-C, Goldman JA, Shih H, Tsai L-H. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 2003, 40:471-483.
  • Gupta A, Sanada K, Miyamoto DT, Rovelstad S, Pearlman AL, Brunstrom J, Tsai L-H.  The layering defect in p35 deficiency is linked to radial migration with improper neuronal-glial interaction.  Nat Neurosci 2003, 6: 1284-1291.

 

2002

  • Ross S, Tienhaara A, Lee MS, Tsai L-H, Gill G.  GC-box binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35.  J Biol Chem 2002; 277: 4455-4464.
  • Patzke H, Tsai L-H.  Calpain-mediated cleavage of the Cyclin-dependent kinase-5 activator p39 to p29.  J BIol Chem 2002; 277: 8054-8060.
  • Tseng HC, Zhou Y, Shen, Tsai LH.  A survey of Cdk5 activator p35 and p25 levels in Alzheimer’s     disease brains.  FEBS Lett 2002; 523: 58-62.
  • Dhavan R, Greer PL, Morabito MA, Orlando LR, and Tsai L-H. The Cyclin-Dependent Kinase 5 Activators p35 and p39 Interact with the -Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and -Actinin-1 in a Calcium-Dependent Manner.  J Neurosci 2002;22(18):7879-7891.
  • Augustinack JC, Sanders JL, Tsai LH, Hyman BT. Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles.J Neuropathol Exp Neurol. 2002 Jun;61(6):557-64.

 

2001

  • Floyd SR, Porro EB, Slepnev VI, Ochoa GC, Tsai L-H, De Camilli P.  Amphiphysin 1 Binds the Cyclin-dependent Kinase (cdk) 5 Regulatory Subunit p35 and Is Phosphorylated by Cdk5 and cdc2 .  J Biol Chem2001;276: 8104-10.
  • Wenzel HJ, Robbins CA, Tsai L-H, Schwartzkroin PA.  Abnormal morphological and functional organization of the hippocampus in a p35 mutant model of cortical dysplasia associated with spontaneous seizures.  J Neurosci 2001;21(3):983-98.
  • Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai L-H.  p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.  J Neurosci. 2001, 21: 6758-71.
  • Tarricone C, Dhavan R, Peng J, Areces LB, Tsai L-H*, Musacchio A*.  Structure and regulation of the CDK5-p25 (nck5a) complex. Mol Cell 2001, 8: 657-69.  *Contributed equally.

 

2000

  • Kwon YT, Gupta A, Zhou Y, Nikolic M, Tsai L-H.  Regulation of the N-cadherin-mediated adhesion by the p35/Cdk5 kinase.  Curr Biol 2000;10:363-72.
  • Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem Biol. 2000 Jan;7(1):51-63.
  • Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai L-H. Neurotoxicity induces cleavage of p35 to p25 by calpain.  Nature 2000;405: 360-64.
  • Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Lanier LM, Gertler FB, Vidal M, Van Etten RA, Tsai L-H.  Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron 2000;26: 633-46.
  • Humbert S, Lanier LM, Tsai L-H.  Synaptic localization of p39, a neuronal activator of Cdk5. Neuroreport2000;11: 2213-16.
  • Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai L-H.  Regulation of cytoplasmic dynein behavior and microtubule organization by mammalian Lis1.  Nat Cell Biol 2000;2:767-75.
  • Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai L-H.  Nudel is a novel Cdk5 substrate that associates with Lis1 and cytoplasmic dynein.  Neuron 2000; 28: 697-711.
  • Tannoch VJ, Hinds PW, Tsai LH. Cell cycle control. Adv Exp Med Biol. 2000;465:127-40.

 

1999

  • Philpott A, Tsai L-H, Kirschner MW.  Neuronal differentiation and patterning in Xenopus:  the role of Cdk5 and a novel activator Xp35.2.  Dev. Biol 1999;207:119-32.
  • Delalle I, Takahashi T, Nowakowski RS, Tsai L-H, Caviness VS Jr.  Cyclin E – p27 opposition and regulation of the G1 phase of the cell cycle in the murine neocortical PVE:  A quantitative analysis of mRNA in situ hybridization.  Cerebral Cortex 1999;9:824-32.
  • Huang D, Patrick G, Moffat J, Tsai L-H, Andrews B.  Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase.  Pro. Natl. Acad. SciUSA 1999;96:14445-450.
  • Bibb JA, Synder GL, Nishi A, Zhen Y, Meijer L, Fienberg AA, Tsai L-H, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC Jr, Nairn AC, Greengard P.  Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.   Nature 1999;402: 669-71.
  • Kwon YT, Tsai L-H, Crandall JE.  Callosal axon guidance defects in p35-/- mice.  J Comp Neurol 1999;415: 218-29.
  • Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai L-H.  Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.  Nature 1999;402:615-22.
  • Humbert S, Dhavan R, Tsai L-H.  p39 activates Cdk5 in neurons, and is associated with the actin cytoskeleton.  J Cell Sci 1999;113: 975-83.

 

1998

  • Kwon YT, Tsai L-H.  A novel disruption of cortical development in p35-/- mice distinct from reeler.  J Comp. Neurol 1998;395:510-22.
  • Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai L-H.  p35, the neuronal specific activator of Cdk5, is degraded by the ubiquitin-proteasome pathway.  J Biol Chem 1998;273:24057-63.
  • Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai L-H.  The p35/Cdk5 kinase is a neuronal specific Rac effector that inhibits Pak1 activity.  Nature 1998;395:194-98.

 

1997

  • Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai L-H.  Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures and adult lethality.  Neuron 1997;18, 29-42.
  • Delalle I, Bhide PG, Caviness VS Jr, Tsai L-H.  Temporal and spatial patterns of expression of p35, a regulator subunit of cyclin-dependent kinase 5, in the nervous system of the mouse.  J Neurocytol 1997;26:283-396.
  • Philpott A, Porro EB, Kirschner MK, Tsai L-H.  The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning.  Genes and Devel 1997;11:1409-21.

 

1996

  • Lee MH, Nikolic M, Baptista CA, Lai E, Tsai L-H, Massague J.  The brain-specific activator p35 allows Cdk5 to escape inhibition by p27kip1 in neurons.  Pro Natl Acad Sci USA 1996;93: 3259-63.
  • Guidato S, Tsai L-H, Woodgett J, Miller CC.  Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5.  J Neurochem 1996;66:1698-706.
  • Nikolic M, Dudek H, Kwon YT, Ramos YFM, Tsai L-H.  The Cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.  Genes and Devel 1996;8:816-25.
  • Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Tsai L-H, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM.  A syndrome of multi-organ hyperplasia with features of gigantism, tumorigenesis and female sterility in p27Kip1-deficient mice.  Cell 1996;85: 733-44.
  • Songyang Z, Lu KP, Kwon YT, Tsai L-H, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, Demaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC.  A structural basis for substrate specificities of protein ser/thr kinases-primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, Cdk5 and ERK1.  Mol Cell Biol 1996;16:6486-93.

 

1995

  • Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai L-H, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E, Fox MP, Wei N. Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell 1995;6: 387-400.
  • Missero C, Calautti E, Eckner R, Chin J, Tsai L-H, Livingston DM, Dotto GP. Involvement of the cell cycle inhibitor Cip1/WAF1 and the transcriptional modulator p300 in terminal differentiation. Pro Natl Acad Sci USA 1995;92: 5451-55.

 

1994

  • Tsai L-H, White L, Raines E, Ross R, Smith RG, Cushley W, Ozanne B.  Expression of platelet-derived growth factor and its receptors by two pre-B acute lymphocytic leukemia cell lines.  Blood 1994:83: 51-5.
  • Tsai L-H, Delalle I, Caviness V, Chae T, Harlow E.  p35, a neural specific regulatory subunit of the Cdk5 kinase.  Nature 1994;371: 419-23.

 

1993

  • Tsai LH, Lees E, Faha B, Harlow E, Riabowol K.  The cdk2 kinase is required for the G1-to-S phase transition in mammalian cells.  Oncogene 1993;8:1593-1602.
  • Tsai L-H, Takahashi T, Caviness V, Harlow E.  Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.  Development 1993;119: 1029-40.

 

1992

  • Faha B, Ewen M, Tsai L-H, Livingston D, Harlow E.  Interaction between human cyclin A and adenovirus E1A-associated p107 protein.  Science 1992;255:87-90.
  • Meyerson M, Enders G, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai L-H.  A family of human cdc2-related protein kinases.  EMBO J 1992;11:2909-17.
  • Cao L, Faha B, Dembski M, Tsai L-H, Harlow E, Dyson N.  Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.  Nature 1992;355:176-179.

 

1991

  • Tsai L-H, Harlow E, Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature 1991;353:174-77.

 

1990

  • Chen Q, Cheng JT, Tsai L-H, Scheneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J 1990 ;9:415-24.
  • Tsai L-H, Nanu L, Smith RG, Ozanne B. Overexpression of c-fos in a human pre-B cell acute lymphocytic leukemia derived cell line, SMS-SB. Oncogene 1990;6:81-8.

 

1988

  • Tsai L-H, Collins MT, Hoiby N. Antigenic analysis of Pasteurella haemolytics serovars 1 through 15 by crossed immuoelectrophoresis. Am J Vet Res 1988;49:213-22.